Rapid Mixer Granulator

The Rapid Mixer Granulator plays a pivotal role in the preparation of Oral Dose Formulations, specifically in Tablet and Capsule Manufacturing. It efficiently mixes various ingredients to form a homogeneous mixture and is widely used in both dry and wet granulation processes.

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Application

  • Widely applicable in the pharmaceutical and chemical sectors

    While primarily used in pharmaceuticals for producing oral solid dosage forms, the Rapid Mixer Granulator also finds applications in other industries such as food processing, agrochemicals, and cosmetics. Its ability to handle a wide range of materials makes it a versatile tool across sectors.

  • Capable of processing dry or wet powder into granules efficiently

    The machine's design allows for the rapid transformation of powders into granules. This process improves flow properties, reduces dust, and enhances compression characteristics of the final product. For pharmaceuticals, this means better tablet quality and reduced variability in drug content uniformity.

  • Significantly reduces batch times

    By combining multiple steps (mixing, granulation, and drying in some models) into one unit operation, the Rapid Mixer Granulator significantly cuts down on processing time. This reduction in batch times translates to increased throughput and more efficient use of manufacturing resources.

  • Efficiency optimization with automation to control process parameters

    Advanced models offer extensive automation capabilities. This includes recipe management systems, data logging, and integration with plant-wide control systems. Such features allow for precise control over critical quality attributes, ensuring consistent product quality and facilitating compliance with regulatory requirements.

  • Maximizes overall productivity in the granulation process

    The equipment's design focuses on maximizing productivity. Features like rapid clean-in-place systems, quick-change product containers, and automated material handling interfaces contribute to reduced downtime between batches.

  • Achieves uniform granulation with reduced friability

    Reduced friability means less dust and fewer fines during subsequent processing steps. This improved granule quality often results in better tablet compressibility, reduced tablet weight variation, and enhanced dissolution properties of the final dosage form.

SPECIFICATION

The Rapid Mixer Granulator is a cornerstone piece of equipment in the pharmaceutical and chemical industries, particularly crucial for the preparation of Oral Dose Formulations. Its primary function is to efficiently mix and granulate various ingredients, creating a homogeneous mixture that forms the basis for tablets and capsules. This versatile machine handles both dry and wet granulation processes, making it an indispensable tool in modern manufacturing facilities.

  • For efficient dry and wet mixing of dry and wet granulation formulation processes

    The machine excels in both dry and wet mixing processes. For dry mixing, it can blend powders of different particle sizes and densities into a uniform mixture. In wet granulation, it efficiently distributes binding liquids throughout the powder bed, ensuring even moisture distribution and granule formation.

  • Programmable logic control for process parameter settings

    This advanced feature allows operators to set, monitor, and adjust critical process parameters such as mixing speed, chopper speed, and granulation time. The programmable nature ensures reproducibility between batches, a crucial factor in pharmaceutical manufacturing where consistency is paramount.

  • Specially designed main blade and chopper for uniform mixing.

    The main blade and chopper are engineered for optimal performance. The main blade, typically a three-armed impeller, provides vigorous mixing action, while the chopper breaks down agglomerates and controls granule size. This dual-action system ensures uniform particle size distribution.

  • Optional: WIP with accessories.

    The Interchangeable Module Platform (IMP) allows for customization of the granulator to suit specific product requirements. Accessories might include spray nozzles for liquid addition, temperature probes for process monitoring, or specialized impeller designs for particular formulations.

  • Capacity: 50 to 1200 liters.

    With sizes ranging from 50 to 1200 liters, manufacturers can choose a model that fits their production scale. Smaller units are ideal for research and development or small-batch production, while larger models cater to high-volume manufacturing needs.

  • Safety interlocks provided for operational safety.

    The incorporation of safety interlocks is critical in pharmaceutical manufacturing. These might include sensors that prevent operation if the lid is open, emergency stop buttons, and systems to prevent overloading or overheating.